Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents
نویسندگان
چکیده
منابع مشابه
Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents.
We report the design and synthesis of a series of non-nucleoside MtbTMPK inhibitors (1-14) based on the gram-positive bacterial TMPK inhibitor hit compound 1. A practical synthesis was developed to access these analogues. Several compounds show promising MtbTMPK inhibitory potency and allow the establishment of a structure-activity relationship, which is helpful for further optimization.
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ژورنال
عنوان ژورنال: European Journal of Medicinal Chemistry
سال: 2020
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2020.112659